Biosensor gene circuit for 3D bioprinted devices

Cell-based therapies have the potential to revolutionize the treatment of chronic diseases such as endocrine and autoimmune disorders, neurological degeneration, and cancer. These treatments utilize cells as localized biofactories to secrete therapeutic molecules. However, one major roadblock in efficiently utilizing cell-based therapies is the cells survival and wellbeing in bioprinted devices. This is due to the vastly different environment in bioprinted devices, resulting in limited access to oxygen and nutrients. This project aims to develop a biosensor system that will measure and report the type and degree of stress that cells undergo in bioprinted devices. It will help Aspect Biosystems develop better bioprinted cell therapies for metabolic disorders, including diabetes and liver diseases.

Faculty Supervisor:

Sheila Teves

Student:

Partner:

Stem Cell Network;Aspect Biosystems Ltd

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

The University of British Columbia

Program: