Calcium Supplements, Elemental Bioavailability, and Uptake by Bone

The goal of this Mitacs research proposal is to develop and apply experimental methodology capable

of distinguishing the influence of calcium supplement dosage form upon elemental calcium uptake,

plasma concentration and spatial distribution in the bone of laboratory rats. In order to achieve those

endpoints, we plan to utilize the compound strontium ranelate, which serves as a consistent, highly

bioavailable dosage form of elemental strontium. Elemental strontium is found in the same column of

the Periodic Table (Group IIA alkaline earth metals) and has the same divalent cationic charge as

calcium, and has been shown to have a natural affinity for uptake by mineralizing bony tissues. Thus,

strontium in effect serves as a surrogate for calcium when given in bioavailable dosage form, with the

advantage that it is not usually found in patient bone, due to the trace amounts present in our dietary

intake. Very much like calcium, strontium will localize to bone where it will become incorporated in………………………………

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Faculty Supervisor:

Mike Doschak

Student:

Partner:

SinoVeda Canada Inc

Discipline:

Life Sciences

Sector:

Agriculture; Manufacturing; Professional, scientific and technical services

University:

University of Alberta

Program:

Accelerate

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