Cell Width Regulation

Bacteria are surrounded by envelopes that are responsible for cell shape and size. Bacterial cell shape and size are important for the organization of intracellular processes, for multicellular interactions, and for infection in case of pathogens. The cell envelope also protects bacteria from the environment. Not surprisingly, it is thus a major target for antibiotics including penicillin. Despite its importance, we lack a fundamental understanding of cell-envelope organization and shape regulation in bacteria and other organisms. Here, we aim to study specifically how cell width is controlled, through a combined approach of live-cell microscopy of cell-shape changes and through computational simulations of the peptidoglycan cell wall. Experiments and simulations will inform each other. Together, this research project will reveal potential design principles of shape maintenance. This research project will be an important learning experience for the student and it will benefit the overarching research on bacterial cell shape of the host lab.

Faculty Supervisor:

Sven van Teeffelen

Student:

Partner:

Indian Institute of Science Education and Research Pune

Discipline:

Life Sciences

Sector:

Life Sciences (not health); Health and Related Sciences & Technology

University:

Université de Montréal

Program: