Cellular regulation of human inducible nitric oxide synthase

The main aim of the project is to find new mechanisms by which Inducible nitric oxide synthase (iNOS) expression is regulated in human cells. Regulation of iNOS through post-translational mechanism stage can give better results. That is why in this project iNOS expression is controlled at the post-translational level.
High concentration of NO can cause tissue damage, and iNOS is the enzyme responsible for the continuous synthesis of NO. The expression of iNOS is tightly regulated by complex molecular mechanisms, involving both translational and post-translational levels. It was found that NO acts in a positive feedback manner to amplify iNOS protein levels. Reduction in iNOS protein degradation is done by mTOR, a kinase that plays a role in the regulation of cell growth, proliferation, survival, and metabolism. Here, we attempt to find how this kinase affects iNOS protein expression. TO BE CONT’D

Faculty Supervisor:

Jonathan Choy

Student:

Partner:

Indian Institute of Technology Kharagpur

Discipline:

Life Sciences

Sector:

Education

University:

Simon Fraser University

Program: