Comparative study of intestinal uptake of eicosaheptaenoic acid (EPA) and docosahexaenoic acid (DHA) from an intrinsically acid-resistant softgel vs a classic non-acid resistant softgel in production swine

GelEntroCeutics have developed an intrinsically acid-resistant formulation of gelatin that was used to make fish oil softgels which are acid-resistant per se and do not need to go through the coating process. This achievement is a major advantage over the usual coating of fish oil capsules with gastric acid-resistant layers that is susceptible to deformation and flaking phenomenon during the coating process. As such, since the bioavailability of active pharmaceutical ingredients also depends on the method of formulation, more so when the dosage form is a delayed-release form, it becomes necessary to evaluate the effect of coating fish oil with an intrinsically acid-resistant formulation of gelatin on the bioavailability of EPA and DHA. This study will determine the safety of this new pharmaceutical, and will investigate if this intrinsically acid-resistant (enteric) softgel affects the plasma levels of DHA and EPA compared to the conventionally enteric coated softgel.

Faculty Supervisor:

Dawei Zhang

Student:

Partner:

GelEntroCeutics

Discipline:

Life Sciences

Sector:

Manufacturing

University:

University of Alberta

Program: