Crystallization-induced asymmetric transformation

Any new tool must match the sensitivity and ease of the best homogenous liquid sampling techniques. It must execute automated slurry capture, phase separation, and sample delivery without perturbing solute-solid equilibria. Our in-line slurry manipulation utilizes EasySampler™ slurry probe, capturing solids and liquids. The sample is delivered via a weak solvent to an inline filter for rapid solid-liquid phase segregation. This supernatant is analyzed to quantify dissolved components. Crystals are then rinsed, dried, dissolved and analyzed through high-performance liquid chromatography (HPLC). Proof of concept involves accessing enantiopure atropisomers, crucial for advanced materials. A recent example involving Bruton’s tyrosine kinase inhibitor highlights the challenge. We aim to employ real-time analysis of dynamic slurry systems to develop CIAT routes to access traditionally inaccessible atropisomers. Our methods could provide access to an entire category of asymmetric molecules via optimized CIAT. This breakthrough could potentially accelerate pharmaceutical development, countering significant R&D barriers.

Faculty Supervisor:

Jason Hein

Student:

Partner:

Université de Rouen Normandie

Discipline:

Physics

Sector:

Education

University:

The University of British Columbia

Program: