Design and screen novel cell-penetrating peptides intracellular delivery of proteins

This project focuses on improving the delivery of a therapeutic protein called ribonuclease (RNP) into cells, which could help treat certain genetic diseases. The challenge with current delivery methods is that the proteins often have trouble getting inside the cell and reaching the nucleus, where they are most needed. To address this, Sinedore Bioscience, in partnership with UBC, is working to develop better versions of cell-penetrating peptides (CPPs) that act as “carriers” to help proteins enter cells more efficiently. By using computer models to design new CPPs and testing them in the lab, the team aims to create peptides that significantly improve protein delivery. This will help Sinedore advance its drug delivery technologies, potentially leading to new treatments for genetic diseases.

Faculty Supervisor:

Shyh-Dar Li

Student:

Partner:

Sinedore Bioscience;MMC Research Institute for Anti-aging

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

The University of British Columbia

Program: