Development of fast photocrosslinking bioinks for visible light-based stereolithography 3D bioprinting

The research projects aims to develop the fast photocrosslinking bioinks for visible light-based stereolithography 3D bioprinting.
In order to prepare bioinks for 3D bioprinting, alginate was modified with tyramine which is phenol group and gelatin was modified with glycidyl methacrylate. Compound with alginate-tyramine derivatives(Alg/Tyr) and gelatin-methacrylate(GelMA) will improve its 3D printability, mechanical properties and cell interaction.
The requirments of bioinks for 3D bioprinting are fast gelation time, excellent cell proliferation and mechanical properties. The gelation time of bioinks will be promoted with tyramines of Alg/Tyr, methacrylates of GelMA and tyrosines of gelatin. In order to supplement the limited cell adhesion of alginate, gelatin will play good cell interactions. With its photo-crosslinking between several phenol and methacrylate moieties, the mechanical properties of Alg/Tyr and GelMA compounds will be enhanced.
Consequently, this project will be successfully accomplished by Professor Keekyoung Kim’s diverse research experience and the ability to conduct advanced research on 3D bioprinting.

Faculty Supervisor:

Keekyoung Kim

Student:

Partner:

Chungnam National University

Discipline:

Engineering

Sector:

Biotechnology; Advanced Manufacturing; Health and Related Sciences & Technology

University:

University of Calgary

Program: