Development of peptide formulations to treat antimicrobial resistant infections

Excessive use of antimicrobials results in the evolution of antimicrobial resistant microbes, and the infection caused by such microbes are known as antimicrobial resistant (AMR) infections. AMR infections are on the rise and has a negative impact on the quality of life, healthcare system and ultimately on the economy. The current proposal aims at the external activation of one’s immune system as an alternative to the use of antimicrobials to treat AMR infections. The objective is to develop a topical formulation that can trigger a controlled activation of immune cells, which will fight clear the microbial load and consequently, aid in the healing of infected wound. The formulation will consist of nanoparticles made up of bioactive peptides and a base material, which will be applied locally to clear the infections.

Faculty Supervisor:

Larry Unsworth

Student:

Partner:

North Forge

Discipline:

Engineering

Sector:

Education; Management of companies and enterprises; Professional, scientific and technical services

University:

University of Alberta

Program: