Dynamic ion speciation during hydrolysis of aryltrifluoroborates

The Suzuki-Miyaura (SM) coupling reaction is a widely studied reaction between organoboron compounds and organic halides. Over the last 30 years the reaction has been improved as new discoveries are made in relation to the reactant species. Its applications extend to pharmaceutical and natural product synthesis due to its versatility. Unfortunately, several of the mechanisms involved in the SM reaction have yet to be uncovered. Pressurized Sample Infusion Electrospray Mass Spectrometry (PSI-ESI-MS) is a technique that has successfully be used to elucidate catalytic mechanisms in the past, and we wish to apply this methodology to demystify the SM reaction. Increased understanding of the reaction could lead to a wider scope and further applications.

Faculty Supervisor:

Scott McIndoe

Student:

Partner:

University of Edinburgh

Discipline:

Physics

Sector:

Education

University:

University of Victoria

Program: