Evaluation of co-delivery of anti-cancer drugs using a handheld injection device

The goal of this proposal is we aim to develop an injectable drug delivery system for intratumoral delivery of a combination of an AXL-inhibitor and FDA-approved chemotherapy drug (e.g.Dox). AXL inhibitors in combination with chemotherapies that target the DNA of cancer cells is a promising approach for treating cancers. The device is integrable to a transformative technology that uses a catheter-based locoregional approach to deliver bioengineered biomaterial. The provided combinational therapy can induce a more efficient ischemic cell death within the tumor microvasculature coupled with an efficient immunotherapy delivery. We will evaluate the co-treatment of cancer cells with the aforementioned drugs and will systematically test their combinations on different cancer cells and analyze the resultant molecular effects by quantitative cell biology methods.

Faculty Supervisor:

Mohsen Akbari

Student:

Partner:

Massachusetts Institute of Technology

Discipline:

Engineering

Sector:

Education

University:

University of Victoria

Program: