Evaluation of the synergistic effect of surface grafted peptides promoting stem cell osteoblastic differentiation

This research project aims to mimic the extracellular matrix by decorating the surface of a biomaterial with molecules that can interact with cells. This interaction causes changes within cells depending on the cell type and the type of molecules involved. We will evaluate the effect of four molecules/peptides distributed in different combinations on the surface of a material to choose the combination that has a remarkable synergistic effect in inducing stem cell differentiation toward bone cells. This will lead to understanding the mechanisms that regulate the interaction between cells and the microenvironment, thus developing new biomaterials that can be used in tissue engineering for bone tissue regeneration.

Faculty Supervisor:

Gaétan Laroche

Student:

Partner:

Université Bordeaux Montaigne

Discipline:

Life Sciences

Sector:

Education

University:

Université Laval

Program: