Examining the effects of Neuropeptide Y5 receptor antagonsim onprimary tumor growth in murine model of breast cancer

Our laboratory has recently provided evidence that NPY is also involved in the progression of breast cancer. We have

demonstrated that breast cancer tumors have sympathetic nerves, NPY and NPY receptors. Also, we

have shown in cell culture studies, that when NPY binds to the Y5 receptor on breast cancer cells,

those cells will divide at a greater rate. Therefore, in the proposed project we will test whether treating

tumor bearing mice with a specific Y5 receptor blocker will slow tumor growth. Tumor bearing mice will be treated daily with a Y5 receptor blocker provided by Triphase Accelarator. Tumor growth will be monitored during a two month period.

Faculty Supervisor:

Dwayne Jackson

Student:

Partner:

Triphase Research and Development II Corp

Discipline:

Life Sciences

Sector:

Administrative and support, waste management and remediation services; Professional, scientific and technical services

University:

Western University

Program:

Accelerate

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