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Expansion and commercialization of in vitro screening assays for thedetection and assessment of endocrine disrupting potentials of chemicals, waste- anddrinking-water
The US Environment Protection Agency (EPA), the Organization for Economic Cooperation and
Development (OECD), and numerous other regulatory bodies in North America, Europe and Asia are
collaborating on the development of programmes to test commercial chemicals, effluents, and (drinking)
water resources for their potential to affect human and environmental health by interacting with the
endocrine system. Since 2009, conformance with some of these programmes (e.g. EPA’s Endocrine
Disruptor Screening Programme) is legally binding for companies that offer their chemical on the US
market, and similar developments are expected in the near future for Canada, Europe and Asia. The
overall goal of this project is to improve and/or develop cellular in vitro systems in support of these
programmes, some of which were already developed by our group. These in vitro systems will be based
on commercially available cell lines that will then be modified such that they express specific
characteristics required for their utilization as screening tools to identify specific endocrine…
Faculty Supervisor:
John Giesy
Student:
Partner:
ENTRIX Inc
Discipline:
Earth science
Sector:
University:
University of Saskatchewan
Program:
Accelerate
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