Expression patterns of Wnt/?-catenin signaling pathway components in colon cancer

Extensive research focused on the identification of cellular signaling pathways involved in cancers. A tumor suppressor SOX7 has been implicated in several human cancers: it has been shown to suppress the Wnt/?-catenin signaling that is highly activated in breast cancer and ovarian cancer. This study sets out to determine the role of SOX 7 and other components of the Wnt/?-catenin signaling pathway in colon cancer. Expression levels of a variety of Wnt/?-catenin pathway associated genes will be determined in a large number of clinical tissues. A high throughput genomics analysis will be used to identify correlations between expression levels and cancer type/stage and establish the putative role of these components in the development and progression of colon cancer. This work identifies target genes for the future development of cancer diagnoses and therapies.

Faculty Supervisor:

Guido van Marle

Student:

Partner:

Harbin Medical University

Discipline:

Life Sciences

Sector:

Education

University:

University of Calgary

Program: