Functional long non-coding RNAs in the 3D structure of the genome

Previous research has shown that most of the mammalian genome is transcribed, while most mammalian transcripts do not code for proteins and may instead be functional themselves. Non-coding RNAs play critical roles in some of the most fundamental processes in molecular biology. The vast majority of mammalian non-coding transcripts are constituted by long non-coding RNAs (lncRNAs) while we know little about their biological function. The FANTOM (Functional Annotation of the Mammalian Genome) projects have played a key role in the discovery of long non-coding RNAs and their biological importance. FANTOM is a large consortium effort led by RIKEN in Yokohama, generating large transcriptomic and genomic data sets which are then shared for analysis with the FANTOM consortium, consisting of ~100 laboratories worldwide. TO BE CONT’D

Faculty Supervisor:

Lisa Strug

Student:

Partner:

RIKEN (Center for Life Science Technologies)

Discipline:

Life Sciences

Sector:

Biotechnology; Health and Related Sciences & Technology; Life Sciences (not health)

University:

University of Toronto

Program: