Generating potent Interleukin-2 variant to specifically enhance NK cell proliferation

A human protein “interleukin-2” plays a key role in immunity. The target of this project is to modify this protein, triggering more immune cells in body, and hence enhancing body defense. At first, the intern will produce normal interleukin-2 in bacteria. The protein will then be mixed with the immune cells. Increase in cell amount indicates the protein is functional. Afterwards, the intern will modify the interleukin-2 at different positions, followed by combining these modifications randomly to create a library of various interleukin-2. They will be tested by using immune cells. The expected outcome is to generate a modified interleukin-2 which strongly promotes immune cell growth. Since the partner organization is a startup company with limited manpower and funding, the intern speeds up the research progress and eases financial burden.

Faculty Supervisor:

Nika Shakiba

Student:

Partner:

Polytide Technology Inc.

Discipline:

Life Sciences

Sector:

Biotechnology; Life Sciences (not health); Health and Related Sciences & Technology

University:

The University of British Columbia

Program: