Glutamate-induced allosteric potentiation of GABAA receptor: a novel mechanism of Purkinje cells inhibitory plasticity

Our brain is controlled by two systems: excitatory systems and inhibitory systems. The balance between these two systems is essential for normal brain functions. Our lab has found that glutamate, a key neurotransmitter in excitatory systems, can act at GABAAR, a key receptor in inhibitory system, and improve GABAAR’s function. This is a novel form of crosstalk between excitatory and inhibitory systems. To study the physiological significance of this phenomenon, our lab has collaborated with Dr. Zhifang Dong’s lab to generate two genetic knock-in mouse strains. In these mice, glutamate can no longer act on GABAARs. In my project, I will use these types of mice to study if this novel glutamate/GABAAR crosstalk contributes to the cerebellar Purkinje cells regulation. Once confirmed, this glutamate/GABAAR crosstalk can be a novel therapeutic target for treating Purkinje cell-related disease, such as motor deficiency and autism.

Faculty Supervisor:

Yu Tian Wang

Student:

Partner:

Chongqing Medical University

Discipline:

Life Sciences

Sector:

University:

The University of British Columbia

Program:

Globalink Research Award