High throughput tissue distribution study of polymer-lipid nanoparticle formulations using DNA barcode technologyy

Our project aims to develop polymer-lipid hybrid nanoparticles (pLNPs) to enhance gene delivery to cells
throughout the body, addressing two major challenges: ineffective release of genetic material inside cells
and limited targeting of non-liver tissues. By incorporating a pH-sensitive material, our pLNPs are designed
to improve the release of their genetic cargo within cells while expanding their reach beyond the liver. This
innovation has the potential to significantly advance gene therapy, which involves delivering therapeutic
genes for various diseases. We will employ advanced techniques to create and test a diverse range of
pLNP formulations in living organisms, establishing a library of unique delivery systems. Ultimately, this will
enable us to select the most effective formulations for precise and efficient gene delivery tailored to specific
diseases.

Faculty Supervisor:

Shyh-Dar Li

Student:

Partner:

GeneStar Bioscience

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

The University of British Columbia

Program: