Impact of Lactobacillus rhamnosus R0011 and its secretome on innate immunity – analysis at the transcriptional level

Bacteria co-existing with us by living in our intestines are important for maintaining our health. However, there are still many questions about how these probiotic or health-promoting bacteria act to influence health, and how to use them to combat the numerous health problems associated with inflammation. The objective of this research project is to determine how products made by one of these bacteria, Lactobacillus rhamnosus R0011, influence the activities of certain cells important in our immune defences: intestinal epithelial cells and macrophages. We found that products of L. rhamnosus R0011 can modify the behavior of these cells in ways that would reduce inflammation. Examining how the products of these bacteria control gene expression in intestinal epithelial cells and macrophages will allow us to more accurately determine the impact on our immune defences and understand how they influence health, information of use to Lallemand Health Solutions for applications of probiotic bacteria.

Faculty Supervisor:

Julia Green-Johnson

Student:

Partner:

Lallemand Bio Ingredients

Discipline:

Life Sciences

Sector:

Agriculture; Manufacturing; Professional, scientific and technical services

University:

University of Ontario Institute of Technology

Program: