Improved and predictable bone regeneration using synthetic dicalcium phosphate grafts containing a novel bone anabolic conjugate

Dental implants are commonly used to replace missing teeth. There are several surgical techniques used with bone replacement materials to achieve alveolar bone regeneration. Dicalcium phosphate cements such as monetite, are synthetic materials made very easily and get removed as bone is regenerated within or around them. C3 is a novel drug that is a combination of a bone targeting drug and a bone formation accelerating molecule. When used alone these targeting drugs make the bones brittle as they block the cells that naturally eat bone. Along with this, we have attached the bone formation accelerator but have made a substitute that only affects the bone causing bone regeneration without the undesirable health effects. We are using monetite grafts loaded with C3 drug and testing them in animal models to get more predictable and greater bone formation ultimately allowing in future benefit to millions of patients undergoing dental therapy.

Faculty Supervisor:

Marc Grynpas;Michael Glogauer

Student:

Partner:

Mesentech Inc

Discipline:

Engineering

Sector:

Professional, scientific and technical services

University:

University of Toronto

Program: