In-Vitro Analysis of Cardiac Tissue Under Severe Strain

The main goal with this research project will be to investigate the effects of strain on cardiac tissue using in-vitro studies. This proposed research will look to analyze high levels of strain in cardiac tissue using equipment that can stretch cells, which was designed and is currently being used in the physiology lab at Bern University, where my research will take place. Regarding the methods of the research, we will induce high levels of strain on the cardiac tissue, and test to see what electrical response we get due to these dynamic strain loads.
By determining if high strain on the cardiac tissue can affect electrical signals of the heart, we can determine if it is the cause for ventricular fibrillation of the heart. By understanding the effects from severe levels of strain on the electrical response of cardiac tissue, we will be able to establish a deeper understanding of the cause for heart failure from rapid stretch of these cells, which can be used towards the ultimate goal of preventing heart failure occurring in young athletes from impacts to the heart (referred to as commotio cordis).

Faculty Supervisor:

Haojie Mao

Student:

Partner:

University of Bern

Discipline:

Engineering

Sector:

Health and Related Sciences & Technology; Biotechnology

University:

The University of Western Ontario

Program: