In-vivo translation of neuronal cell regeneration/reprogramming protein in mouse with chronic spinal cord injury

Chronic spinal cord injury (SCI) is a debilitating disease with enormous economic and personal impact. To date there is no approved treatment that can repair the severed nerves found in SCI. The research project entails translational development of an early stage experimental protein drug candidate that has shown remarkable ability to trigger dormant human stem cells to rapidly differentiate into functional neuronal populations. Both the drug candidates safe dosage range and efficacy in regenerating neurons at the site of injury will be studied. The goal of the project is to test the feasibility of this protein drug to enter clinical development.

Faculty Supervisor:

Wolfram Tetzlaff

Student:

Chih-Chung Fan

Partner:

iProgen

Discipline:

Medicine

Sector:

Medical devices

University:

University of British Columbia