Investigating Cannflavins as potential antimicrobial agents against antibiotic-resistant pathogens

Antimicrobial resistance is a growing, global problem. Our arsenal of effective antibiotics against drug resistant
bacteria and fungi is quite limited and innovative approaches are needed. Focusing on cannflavins, this proposal
will evaluate if these hemp-derived molecules with anti-inflammatory and anti-bacterial effects (1) are candidates
for interacting with pathogen protein targets, (2) are effective to eliminate drug-resistant bacteria and fungi, and
(3) eliminate azole-resistant vaginal candidiasis in a mouse model and/or improve wound healing in a diabetic
ulcer mouse model. By enhancing the druggability of these compounds and investigating enzyme interaction
pharmacology, and the in vivo activity, the project aims to advance innovative solutions in the battle against
antimicrobial resistance.

Faculty Supervisor:

Ellen Wasan

Student:

Partner:

Canurta Inc

Discipline:

Life Sciences

Sector:

Manufacturing

University:

University of Saskatchewan

Program: