Investigation of antifungal properties of thiazolidine derivates

Infections, caused by the Candida species have emerged as a significant global health concern. These diseases can range from superficial to life-threatening, affecting various body parts. However, the effective management of Candida infections is increasingly challenged by the growing issue of drug resistance.Focusing on that problem, our research project aims to investigate the antifungal properties of thiazolidine derivatives, a class of organic compounds. Thiazolidines have shown promising potential in various biological applications, but their specific antifungal properties remain underexplored.
We will use a variety of laboratory techniques such as detection of MIC concentrations, screening of synergetic action with fluconazole, biofilm and worm assays to establish potencial antifungal activity and possible mechanisms of action. This work will help us in research of new potencial medicines to treat diseases caused by Candida species.

Faculty Supervisor:

Rebecca Shapiro

Student:

Partner:

Ivano-Frankivsk National Medical University

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Biotechnology

University:

University of Guelph

Program: