Miniaturized Carbon Nitride-Based Electrochemiluminescence Assays for Detection of Cardiac Biomarkers

Acute myocardial infarction (AMI) is a life-threatening medical condition, and it remains the primary reason for premature death (persons aged 25–64) worldwide. Therefore, early screening of cardiac biomarkers is critically important for improving survival chances. The existing methods for detecting cardiac biomarkers are multi-step approaches and require laboratory tests, which have higher test times, are expensive, and lack sensitivity. Hence, point-of-care testing provides substantial direction near the patient’s site and shortens the overall turnaround time in clinical diagnosis. This project mainly focuses on developing a miniaturized carbon nitride-based electrochemiluminescence assay to detect cardiac biomarkers. The envisioned novel micro-scaled biosensor will pave the way for rapid, accurate diagnosis of AMI onsite. The focal point of the proposed research is to employ visual electrochemiluminescence as a model analytical method and leverage the distinctive properties of carbon nitride as a sensing material to elucidate the biochemical reaction process efficiently. The application of carbon nitride will provide unique features for detecting ultralow concentration levels by boosting sensitivity and facilitating the electrochemical reaction effectively. The proposed device will also help the medical practitioner understand patients’ cases in the pre-hospital phase, improving the accessibility of cardiac diagnostics at the point of care.

Faculty Supervisor:

Karthik Shankar

Student:

Partner:

Birla Institute of Technology and Science, Pilani

Discipline:

Engineering

Sector:

Health and Related Sciences & Technology

University:

University of Alberta

Program: