Molecular genetic analysis of a novel class of negative regulators of cell proliferation

My research focuses on understanding the mechanism of action of a new class of tumor suppressor genes using the well
established round worm (nematode) model system. Previously published data from Gupta and Chamberlin lab have shown that
deleting the function of these genes causes excessive proliferation of cells (similar to cancerous growth). To further understand
their role, I have carried out several experiments in Gupta lab. My next set of experiments involve generating transgenic strains
for which I will be visiting Dr. Chamberlin’s lab. My results will reveal the mechanistic roles of these genes which will be beneficial
in understanding how their homologs function in restricting cell proliferation in higher eukaryotes. Ultimately, the findings of my
research will lead to a better understanding of genetic mechanisms underlying cancerous growth thereby facilitating in the
development of targeted therapeutics against cancers.

Faculty Supervisor:

Bhagwati Gupta

Student:

Partner:

Ohio State University

Discipline:

Life Sciences

Sector:

Biotechnology; Life Sciences (not health)

University:

McMaster University

Program: