Network Analysis and Mathematical Modeling of Neuron-Astrocyte Multiplex Net

Understanding and predicting brain activity is the main objective of computational neuroscience. Neuronal cells are the building blocks of the brain and responsible for electrical signaling and cognitive ability. Recent studies indicate that another cell type, called astrocyte, plays an important role as well. These cells have been proposed to interact with neurons and modulate properties of neurological networks although the biochemical processes remain unknown. Further research is necessary since astrocytes are likely involved in numerous neurological disorders, including Alzheimer’s disease. In our project, we will analyze underlying astrocyte-astrocyte and neuron-astrocyte interaction networks based on high-quality data sets and mathematically model the dynamic behavior. We hypothesize that interactions between astrocytes and neurons are relevant and that astrocytes actively participate in neuronal signaling. With our mathematical model, we expect to identify essential aspects of astrocyte-astrocyte and neuron-astrocyte interaction, which would close a critical knowledge gap in neuroscience.

Faculty Supervisor:

Joern Davidsen

Student:

Partner:

Goethe University Frankfurt

Discipline:

Life Sciences

Sector:

Life Sciences (not health); Information and Communications Technology; Health and Related Sciences & Technology

University:

University of Calgary

Program: