Pilot Study of micro-OCT (Optical Coherence Tomography) Device for the Detection of Invasive and Pre-invasive Cervical Lesions Ex Vivo

Optical coherence tomography (OCT) is an optical imaging method providing 3D in vivo optical tissue biopsy noninvasively. OCT studies in gynecology has revealed its capabilities for cervical screening due to its high resolution imaging, and sensitivity to both morphological and functional changes, and customized probes. Micro-optical coherence tomography (µOCT), a technology developed at Tearney Lab at Harvard Medical School, captures images of four-dimensional (x, y, z, t) cellular and sub-cellular biological structures with an isotropic 1 µm spatial resolution and 10 ms temporal resolution. The bench top microscope uses a visible broad bandwidth supercontinuum light source to achieve high axial resolution as well as new software and optics that maintain high lateral resolution over an extended focal depth. Studies have shown that µOCT is capable of resolving individual sub-cellular features and their function, all without requiring exogenous contrast agents. TO BE CONT’D

Faculty Supervisor:

Calum MacAulay

Student:

Partner:

Harvard University

Discipline:

Life Sciences

Sector:

Education

University:

The University of British Columbia

Program: