Regulation of ubiquitin specific protease 8 by AMPK-mediated phosphorylation

Parkinson’s disease (PD) is the 2nd most common neurodegenerative disorder, affecting greater than 1% of people over 60. As occurrences are predicted to double in the next 20 years, there is a critical need for the development of prophylactic and/or therapeutic interventions. We have recently identified two enzymes, USP8 and AMPK, that interact and may be involved in mechanisms that lead to the onset and progression of PD. In collaboration with the Parkinson’s Society Southwestern Ontario (PSSO), the interaction of USP8 and AMPK will be explored to determine if they are directly involved in PD or associated cellular mechanisms. The research proposed will add to the growing list of potential therapeutic targets for the fight against this debilitating disease.

Faculty Supervisor:

Yufeng Tong

Student:

Partner:

Parkinson Society Southwestern Ontario

Discipline:

Life Sciences

Sector:

Other services (except public administration)

University:

University of Windsor

Program: