Role of Autophagy in Neurogenesis during Stroke Recovery

In the late 1990s, scientists made the remarkable discovery of neurogenesis in the adult human

brain, defined as the process of new neurons being formed from neural stem cells. This was a

remarkable discovery since it raised hope that we can replace neurons that have died following a

stroke. Thus many researchers are trying to reduce the damage following a strokeby determining how

we canincrease the growth and survival of neural stem cells. The proposed researchwill for the first

time determine whether a process called autophagy plays an important role in the survival of neural

stem cells during stroke recovery. Autophagy is a process that many types of cells use to recycle

materials and we believe that in stem cells autophagy is required for survival in the mature adult brain.

Thus this work will allow us to understand what regulates the survival of stem cells in the brain post

stroke, with the ultimate hope of developing novel treatments for…………….TOBECONTINUED

Faculty Supervisor:

Diane Lagace

Student:

Partner:

Heart and Stroke Foundation of Canada (ON)

Discipline:

Life Sciences

Sector:

University:

University of Ottawa

Program:

Accelerate

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