Screening of coformers to produce drug cocrystals

Approximately 40% of active pharmaceutical ingredients (API) in industry pipeline are poorly water soluble. Due to the limited water solubility, these drugs cannot be developed into full formulations. Producing crystals containing such APIs and other small molecules, makes it possible for this drug molecules to dissolve better and improve their bioavailability. Therefore, in this research the efforts will be focused on developing such crystals for a drug molecule, Curcumin. It is known to be a pharmaceutically viable molecule for several medicinal properties including anticancer properties but suffers from low bioavailability. The focus will be to understand the process of making two-component crystals of curcumin.

Faculty Supervisor:

Sohrab Rohani

Student:

Partner:

Indian Institute of Technology Gandhinagar

Discipline:

Engineering

Sector:

Education

University:

Western University

Program: