Self reporting Tookad-Caspase 3-Pyropheophorbide PDT beacon for PDT/fluorescence imaging of cancer

I plan to make a small molecule probe that reacts to specific colors of light, triggering cell death in the illuminated area in a process called Photodynamic Therapy (PDT) as a method to treat cancer. The probe uses a drug currently being investigated in clinical trials called Tookad© soluble for therapy. This probe also has a component that would react to the cell death in the tumor that is fluorescent, meaning that upon illumination with a specific wavelength of light, it will emit light of a slightly longer wavelength which can be detected for monitoring the tumor post-treatment. This probe would allow for both PDT treatment as well as treatment monitoring, meaning this compound can provide therapy and diagnostics all in one.TO BE CONT’D

Faculty Supervisor:

Xiaosong Wang

Student:

Partner:

The University of Tokyo

Discipline:

Life Sciences

Sector:

Education

University:

University of Waterloo

Program: