SSE – QV Studio – Pritam Priyadarsi

We are pioneering a state-of-the-art instrument that enables 3D imaging of single electron spins in individual spin-labeled biomolecules with unparalleled nanometer spatial resolution in volumes as small as (50-nm)³. This innovative capability allows for the direct determination of coordination among spin-labeled molecules, providing unique insights into the structure of biomolecular complexes that existing technologies cannot achieve. Our instrument incorporates several advanced features to attain exceptional sensitivity in detecting single electron spins within biologically relevant volumes. We utilize ultra-sensitive silicon nanowire mechanical sensors for precise spin detection and employ nanoscale current-driven field gradient sources to facilitate 3D magnetic resonance imaging (MRI). Additionally, we implement optimal control pulse sequences to enhance spin control and achieve long spin coherence times, which are essential for high-resolution imaging. To further increase imaging efficiency, our technology employs compressed sensing measurement protocols, streamlining the data acquisition process and enabling detailed 3D imaging of nanoscale volumes. Collectively, these features position our instrument as a revolutionary tool in biomolecular research, offering unprecedented access to structural details that are critical for understanding complex biological systems. We seek seed funding to commercialize this cutting-edge technology, which has the potential to transform the study of biomolecules and pave the way for advancements in areas such as drug discovery and disease diagnostics.

Faculty Supervisor:

Raffi Budakian

Student:

Partner:

QV Studio

Discipline:

Physics

Sector:

Public administration

University:

University of Waterloo

Program: