Studies of CNNM-TRPM7 complexes

It has recently been shown that the tumour suppressor CNNM and TRPM7 bind each other and are coordinately regulated. We propose to determine the structure and function of the complex using cryoelectron microscopy and ion transport assays. A PhD student from the Gehring laboratory will spend four months working in the Runnels laboratory designing and testing constructs for structural studies. The project takes advantage of the complementary expertise of the two groups: the Gehring laboratory for structural studies, and the Runnels laboratory for cell biological and functional assays. The student will learn techniques of mammalian cell culture and ion transport assays. The skills learned will be invaluable in the student’s future career as an independent research group leader.

Faculty Supervisor:

Kalle Gehring

Student:

Partner:

Rutgers University

Discipline:

Life Sciences

Sector:

Education

University:

McGill University

Program: