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Study the mechanism of action of UM0125461 in acute T cell leukemia (T-ALL)
Acute lymphoblastic leukemia (ALL) is the most common hematological cancer in children. 10 to 15% of pediatric cases are of T cell origin (T-ALL). Current intensive multidrug therapy can achieve high cure rates, yet associated with serious long-term adverse effects, including secondary cancers. Moreover, 15% of children will relapse, facing a poor prognosis. We previously uncovered a new drug using a chemical screen in mouse model of human T-ALL. Unraveling the mechanism of action of this new drug will open novel therapeutic opportunities to treat T-ALL patients.
Faculty Supervisor:
Trang Hoang
Student:
Partner:
Université Catholique de Louvain
Discipline:
Life Sciences
Sector:
Education
University:
Université de Montréal
Program:
Globalink Research Award
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