The Effect of Gut Microbiota Metabolites on Skeletal Muscle Function

Gut bacteria are increasingly appreciated as crucial actors in human physiology. Recent studies have highlighted their potential effect on muscle. For instance, endurance is influenced by the type of bacteria found in the gut. However, the precise mechanism underlying this link is still unknown. We have started to investigate the role of metabolites produced by gut bacteria. Specifically, we are examining the molecular effects of these metabolites on muscle cells. The aim of this project will be to tie these effects to changes in muscle function. We will first examine the functional changes conferred by the metabolites in an established ex vivo and in vitro models of muscle contraction. Moreover, we will develop innovative functional studies in 3D cellular models of human muscle. These findings will lay the foundation for future muscle therapies targeting gut microbes. Moreover, the unique 3D models developed will greatly increase our ability to study human muscle in the future.

Faculty Supervisor:

Benoit Gentil

Student:

Partner:

Université de Montpellier

Discipline:

Life Sciences

Sector:

Education

University:

McGill University

Program: