To Investigate the Role of Prohibitin-1 (PHB1) In the Functional Plasticity of Macrophage

Macrophages are a highly diverse cell type that plays crucial roles in the body such as fighting pathogens, maintaining self-tolerance, surveillancing early cancer cells and tissue repair, whereas dysregulation of these functions are often associated with diseases such as obesity, diabetes, cancers and autoimmune diseases. Up to date, factors that regulate the metabolic switches between macrophage phenotypes are largely unexplored. My PhD focuses on one potential factor named prohibitin-1 in the regulation of macrophage plasticity and functions. I will use a combination of in vivo and in vitro experimental approaches along with molecular biology techniques and proteomics tools. Research findings will give us a better understanding of the integration of cell signaling events with metabolic pathways within macrophages in both normal body physiology and disease states, which may provide potential therapeutic benefits.

Faculty Supervisor:

Suresh Mishra

Student:

Partner:

University of Chicago

Discipline:

Life Sciences

Sector:

Education

University:

University of Manitoba

Program: