TU Berlin Summer Research on Bacteriophage Biology and Structural Analysis

This project investigates the SPbeta bacteriophage, a model organism in phage biology with significant implications for microbiology and biotechnology. The primary objective is to develop and refine methods for its purification and biochemical characterization, enabling a detailed analysis of its structure and function. Using targeted deletion mutants, we aim to identify key genes and proteins involved in its assembly. Advanced cryo-electron microscopy will provide high-resolution visualization of the phage’s architecture, assembly pathways, and interactions with its host. These insights will enhance our understanding of bacteriophage biology and support applications such as phage-based therapies, biotechnological tools, and improved models for viral assembly and evolution. This collaborative effort between the University of Calgary and Technische Universität Berlin integrates expertise, resources, and cutting-edge research facilities. By working together, the institutions aim to drive innovation in bacteriophage research while creating valuable training opportunities for students and researchers. The project not only contributes to advancing scientific knowledge but also fosters strong ties between the institutions, paving the way for future collaborations in microbiology and biotechnology.

Faculty Supervisor:

Xiaofan Jin

Student:

Partner:

Technische Universität Berlin

Discipline:

Life Sciences

Sector:

Biotechnology; Health and Related Sciences & Technology; Life Sciences (not health)

University:

University of Calgary

Program: