Up-regulation of the antigen presentation machinery in metastatic cancer using small molecules

As a primary cancer progresses to the deadliest form, metastatic cancer, the cells undergo several genetic and epigenetic alterations referred to as the metastatic gene signature. Part of a metastatic gene signature is the downregulation of genes associated with immune recognition, which can be seen in multiple cancer types as the down regulation of the antigen presentation machinery (APM). This internship project will contribute to the collaborative investigation of APM and its potential as future therapeutics in the prevention of cancer progression.

Faculty Supervisor:

Wilfred Jefferies

Student:

Samantha Ellis

Partner:

BioMmune Technologies Inc

Discipline:

Genetics

Sector:

Medical devices

University:

University of British Columbia

Program:

Accelerate

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