Violacein effects in mice Rho 264.7 cells

Violacein is a molecule naturally produced in some bacteria such as Chromobacterium violaceum. It has been shown that violacein has promising antibiotic, anti-tumor proliferation, anti-leishmanial and anti-fungal properties. Violacein is commercially available. However, it is very expensive. The objective of this proposed research study is to measure the effects of violacein produced by Escherichia coli on mice Rho 264.7 cells. Over a four month period the intern will use biotechnology techniques to accomplish the objective of this project. When this project is finish, there is an expected benefit to Synbiota Inc. as the software tools, as well as storage and management of the associated scientific data were developed and are maintained by Synbiota Inc. Moreover, the reagent kit used to generate the violacein producing E.coli was co-created by Synbiota Inc. and partner Genomikon Inc. Further characterization of the violacein producing E.coli as well as the efficacy of violacein is of importance for quality control metrics and validation that the reagent kit holds value in the research community. The results of this project will be of value for Synbiota Inc. assisting in the development and marketing of the company’s products.

Faculty Supervisor:

Jeffrey Fillingham

Student:

Partner:

Synbiota

Discipline:

Life Sciences

Sector:

Biotechnology; Life Sciences (not health); Pharmaceuticals

University:

Toronto Metropolitan University

Program: