Microneedles are miniaturized needles, typically with lengths below 1 mm and often arranged into an array. These properties are ideally suited for breaching the skin’s outermost layers without activating pain-sensing neurons deeper in the tissue, which has led to much interest in using MNs for interfacing with the skin. One such application consists of using […]

Plants are always exposed to and attacked by pathogenic microbes in natural environment. Phytoalexin deficient 4 (PAD4) plays an important role in plant defense to pathogens. PAD4, EDS1 and SAG101 form a specific family containing lipase domain at N-termini. PAD4 interacts with EDS1, but not SAG101 to form heterologous complex. Recently, we demonstrated tha PAD4 […]

Dysfunction of mitochondria, the cellular powerhouses, plays an important role in a plethora human disorders, including rare genetic myopathies such as Duchenne Muscular Dystrophy (DMD). Mitochondrial dysfunction also causes stem cell abnormalities in several tissues including skeletal muscle. For this reason, modulation of mitochondrial quality is increasingly proposed as a therapeutic strategy to prevent/restore cellular […]

Le circuit innovant de mycoremédiation que nous proposons permettra non seulement de décontaminer plusieurs gisements de résidus problématiques provenant des industries du textile, de l’alimentation et de la construction, mais aussi d’éco-concevoir une alternative au polystyrène pour la protection et l’isolation. Déjà au stade de la preuve de concept avancée, ces myco-matériaux, littéralement tissés par […]

Le cancer du sein représente un défi majeur en matière de santé publique et demeure la deuxième cause de mortalité chez les femmes par cancer dans le monde. Chaque année, 670 000 femmes perdent la vie à cause de diagnostics tardifs et de rechutes dans le cancer du sein, stades où malheureusement la réponse aux […]

“THIS IS A GENERIC TEXT PUT IN PLACE AS THERE WAS NO PROJECT OVERVIEW”

Combining multiple methods like MEK (Traditional Ecological Knowledge), environmental DNA (eDNA) analysis, and traditional wildlife surveys can provide a comprehensive approach to determine the historical and current distribution of wood turtles (Migjigj) in the Matapedia-Restigouche watershed. This approach not only enhances the accuracy of findings but also respects and integrates diverse knowledge systems, contributing to […]

A key aspect of human behaviour is the ability to flexibly interact with our dynamic environment. From a baby learning to walk, to a pilot flying a plane, humans rely on their ability to acquire relevant information from the environment, integrate that information into their planning and decision making, and generate the necessary actions successfully. […]

Improving the quality of X-ray imaging and radiation therapy is crucial to the efficacy of cancer treatments. Recently, hafnium dioxide nanoparticles (HfO2 NPs) have been approved in the European Union as a radiosensitizer and are currently in clinical trials in the United States. This is based on hafnium’s ability to amplify local radiation doses by […]

Worldwide, untreatable retinal degeneration & damage results in a staggering amount of suffering for >85 million blind patients across all age groups. In Canada, severe vision loss incurs the highest direct healthcare costs of any disease group (including: heart disease, diabetes, and cancer) – averaging $33,000/patient/year. While globally, age-related macular degeneration alone has an economic […]

Over the next 20 years, Canada’s senior population is expected to grow by 68% with a current estimate >6 million. In France, senior citizens currently represent 20% of the population (~15 million) with, like Canada, an anticipated growth of 67% by 2040. Age is the main cause of cognitive impairment which can have profound impact […]

Our proposed project involves developing the Osteoprobe, a cutting-edge tool designed to help surgeons accurately identify and remove bone cancer during surgery. By using advanced technology, including spectroscopy and artificial intelligence, the Osteoprobe provides real-time information, ensuring that only cancerous tissue is removed and healthy tissue is preserved. This innovation is expected to significantly improve […]