3D Printing of Beta-Tricalcium Phosphate constructs for Post Cancer Maxillectomy Patients

The maxillectomy is a surgical procedure, involving the removal of parts of the maxillary bone due to either congenital defects, traumatic conditions, or osteogenic and non-osteogenic tumors. The current gold standard of treatment involves the auto-grafting of bone from a second surgical site such as the fibula, into the maxilla; a practice that increases the risk of site morbidity, graft failure, and infection. The goal of this study, is to investigate the potential and utility of beta-tricalcium phosphate (B-TCP), a novel biocompatible and bioresorbable ceramic, as a suitable bio-material for 3D printed prosthetics, set to replace bone grafting as the gold standard procedure in maxillofacial reconstructive surgeries. While closely resembling human bone, B-TCP provides a scaffold that promotes bone regeneration and can also resorb to create space for new bone tissue to take its place. While utilizing the innate properties of B-TCP, there will be additional doping of novel bone anabolic conjugate (MES 1007), to amplify the regeneration process. The application of 3D printing allows for grafts customized to the patient’s defect aiding in reconstruction and reducing surgical time. Increased biocompatibility limits the risk of graft failure and leads to shorter recovery times.

Faculty Supervisor:

Zeeshan Sheikh

Student:

Partner:

New York University

Discipline:

Life Sciences

Sector:

Education

University:

Dalhousie University

Program: