Evaluation of the effect of butyrate supplementation on the expression of circadian genes, inflammation, sleep quality and psychological factors in patients with ulcerative colitis

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD). Although its prevalence is rapidly rising worldwide, the pathophysiology and definite treatment of IBD is yet unknown. In particular, Canada is among countries with the highest IBD prevalence. Recently, circadian rhythm disruption has received significant interest for the IBD pathophysiology. In addition IBD patients […]

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Improving the clinical oculomotor assessment for patients with multiple sclerosis

Clinicians’ ability to detect abnormal eye-movements has powerful implications for the diagnosis, monitoring of disease progression and evaluation of therapeutic outcomes in patients with multiple sclerosis. Despite the advantages of the oculomotor assessment, standard clinical practices are limited and do not capture the dynamic aspects of eye-movement. Sophisticated methods have been developed in the laboratory […]

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Développement et qualification d’une approche de type point-of-care (POC) pour le dosage de la ferritine plasmatique par résonance des plasmons de surface (SPR)

Chez un donneur de sang fréquent, il arrive d’observer une chute des réserves de fer1,2. La mesure du taux d’hémoglobine dans le sang des donneurs permet aux banques de sang d’éviter de prélever un individu pour qui les réserves de fer seraient considérées comme étant faibles. La ferritine est un marqueur précoce de la carence […]

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Study of Amaryllidaceae alkaloid pathway genes using comparative Omics analysis

Plant produce large number of the bioactive compounds, among them Amaryllidaceae alkaloids has such potential. Those Amaryllidaceae alkaloids are extracted from Amaryllidaceae plant family. Galantamine is one of the drug which is derived from the Amaryllidaceae alkaloid pathway; and is the only commercialized drug for the treatment of early symptoms of Alzheimer’s disease. Although many […]

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Développement d’un modèle pharmacocinétique populationnel pour prédire l’exposition des nourrissons à la Sertraline via le lait maternel

La sertraline est un médicament fréquemment utilisé dans la période postnatale afin de traiter la dépression. Cependant, il existe peu de données sur le passage de ce médicament dans le lait maternel et sur ses effets sur les enfants allaités. Une étude clinique est présentement en cours afin de quantifier la sertraline dans le lait […]

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Ozone nano-bubbles for improved control of meat spoilage

The muscles of animals are generally sterile, however, contamination with bacteria occurs during slaughter. Contamination occurs predominantly with microorganisms associated with the animals with microorganisms that reside in biofilm communities in the meat processing plant. Bacteria that reside in biofilm communities typically grow at refrigeration temperature and include major spoilage organisms of meats and meat […]

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Localized node-based collection of wastewater samples for molecular monitoring of public health markers

Wastewater testing can measure levels of COVID-19 in a population that is contributing to the sewer system being monitored. This testing provides an early warning signal of the burden of COVID-19 in municipalities, independent of clinical testing. Calgary based start-up company C.E.C. Analytics (CEC) has developed a compact wastewater autosampler that enables this kind of […]

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Evaluate the impact on transmission dynamics and cost-effectiveness of pertussis booster vaccine for Canadian adolescents and adults

Pertussis or whooping cough is caused by the strict human pathogen B. pertussis or Bordetella parapertussis and is a highly contagious, potentially life-threatening respiratory tract illness when it occurs in unprotected infants. Despite the introduction of acellular pertussis (aP) vaccines and great initial success of the immunization program, pertussis outbreaks were reported in adolescents and […]

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Promoting OMICS for the non-invasive screening for subclinical arterial disease in heart transplant patients

Heart transplantation is the definitive therapy for patients with end-stage heart failure. Each year, over 5000 heart transplant procedures are performed worldwide. One of the main limitations to the long-term survival of heart transplant recipients is the diffuse narrowing of the coronary arteries, called cardiac allograft vasculopathy (CAV, also known as transplant coronary artery disease). […]

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Experiences, Barriers, and Factors Influencing Career Advancement Among Internationally Educated Nurses in Home Care

The home care sector suffers from workforce inefficiencies with many of its healthcare providers not working to their full potential. This includes internationally educated nurses (IENs) who have obtained their education in a foreign country but are not certified in Canada. In addition to their professional expertise, IENs have multilingual and multicultural skills and perspectives, […]

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