G protein coupled receptors (GCPRs) are proteins found at the surface of cells are responsible for activating numerous intracellular signaling pathways and thus are involved in regulating about every physiological response. Activation of GPCRs occurs via a diverse array of stimuli as varied as photons, lipids, ions, small hormone or neurotransmitters through to larger peptidic […]

Developing safer, more effective treatments for chronic pain has become a major area of research due to the negative side effects of opioids. This project aims to mediate the intelligent design and development of drugs, that will achieve pain relief without the detrimental side effects of addiction and respiratory depression. The proposed research will use […]

Dans le cadre d’une restructuration, Orica souhaite réhabiliter une partie de son site localisé à Brownsburg-Chatham au Québec. Le site qui accueille depuis 1870 une usine de production d’explosif est non seulement contaminé, mais présente des risques importants pour les écosystèmes et la santé humaine. Ainsi, l’entreprise souhaite développer une approche verte qui vise à […]

We propose to develop in collaboration with Medtronic Canada a bioceramic drug delivery system for the local controlled release of Biphosphonates (BP) – drugs that prevent bone resorption – to promote both tumor inhibition and bone regeneration at the site of bone tumor resection, eliminating the need for high systemic doses and side effects associated […]

After legalisation, cannabis use has become more widespread, and consumption has increased in Canada. There is a need for more insight into the extent of impairment caused by cannabis in adults. The goal of this proposed research project is to determine the degree of impairment in adults after cannabis ingestion. We will study the effect […]

Ensuring biodiversity is maintained as Edmonton continues to grow is vital in maintaining Regional connectivity and ensuring long term sustainability of the City’s natural systems and the ecosystem services that it provides to Edmonton’s residents. The goal of this project is to identify public open space site characteristics that are associated with increased (or decreased) […]

This project focuses on the development of an automated system to detect images consisting of skin moles. The detection of images consisting of moles will play a central role in dermatology screening using telemedical and virtual healthcare platforms. Upon classification, images consisting of moles will be sent to specialists for further diagnosis and treatment procedures. […]

Les causes des maladies cardiovasculaires sont multifactorielles; certaines sont génétiques, d’autres liées intimement aux habitudes de vie et d’autres tombent dans ce qu’on appelle l’épigénétique. Ce domaine étudie les influences environnementales sur l’expression de nos gènes et se subdivise en plusieurs sous-spécialités de recherche. Au cours de notre projet, nous étudierons les influences des protéines […]

The long-term effects of COVID-19 on individual health remain to be elucidated, with numerous reports emerging of fibrotic changes in the lung beyond the acute phase of the disease. Considering the reported cases of COVID-19 worldwide, even a small percentage of these patients developing lung fibrosis can have detrimental consequences on our healthcare system. In […]

The goal of the study is to track Chinook Salmon migrations and determine the factors that influence an individual’s migration decisions. We will catch juvenile Chinook Salmon and release them back into the ocean after placing small electronic devices inside their bodies that will allow us to track their migrations. As a result, we will […]

PharmAla have been focusing on developing MDMA (ecstasy) like drug compounds. MDMA assisted psychotherapy for treatment of PTSD received Breakthrough Therapy designation in August 2017. It is currently being evaluated in Phase 3 clinical trials. The toxicological biochemical mechanism of MDMA and MDMA like compounds should be better understood. Because of this gap an extensive […]

Timing and time perception is found to be modulated by different brain networks. Nowadays, many non-invasive instruments are widely used to stimulate the brain and among them is transcutaneous vagus nerve stimulation (tVNS), which is a painless and non-invasive technology that gives the ability of modulating brain networks including the ones that are involved in […]