Bacterial resistance to aminoglycoside antibiotics is a major public health problem. The WHO (World Health organization) has highlighted the urgent need to find new treatments to fight multidrug resistance MDR bacteria, as actual drugs are less effective or inactive. This research project aims to develop new chemical compounds to restore bacterial sensitivity to antibiotics currently […]

Serial electron diffraction (serial-ED) crystallography is an emerging structural biology method whereby data are collected from protein nanocrystals using a sub-micron-sized electron beam. The method is set to lead the future of nanocrystallography, given its cost-effectiveness and the small amount of sample required. Combining the expertise of the Colletier and Miller teams, the project will […]

La métabolomique est une science prometteuse pour identifier de nouveaux marqueurs biologiques associés à l’insuffisance cardiaque à fraction d’éjection préservée (HFpEF), afin d’améliorer son diagnostic et son traitement. Notre projet vise l’utilisation de méthodes de bioinformatiques et d’intelligence artificielle pour l’analyse de données métabolomiques et lipidomiques de patients HFpEF, précédemment générées et prétraitées dans nos […]

Objectives: The objectives of this study are to use in vitro and in vivo models to validate the hypothesis that the ironchelator, DIBI, can selectively inhibit the proliferation and survival of breast cancer cells and that the combination of this chelator with radiation or standard chemotherapeutic agents (e.g., cisplatin and docetaxel) increases the sensitivity of […]

An organism’s genome contains the information necessary for its development. Part of this information is used as “instructions” for cells to synthesize molecules called proteins, which perform most of the cell’s functions. However, over time, changes to the genomic information can occur. These changes (mutations) can have all kinds of effects: some might cause diseases, […]

Cholinergic compounds can act as both pharmaceuticals and bioactive compounds in functional foods. Alpha-Glycerylphosphoryl choline (alpha-GPC) is a known cholinergic compound that is used in Korea as a prescription pharmaceutical for treatment of Alzheimer’s disease. However, development as a functional food and related researches in Korea is limited. Recently, the team led by Dr. Martin […]

L’objectif du projet présenté ici est d’établir le potentiel d’utilisation de plantes indigènes et de leur combinaison face à la décontamination du triclosan au sein d’infrastructures phytotechnologiques innovatrices ; des marais filtrants intégrés aux paysages québécois. Pour ce faire, des marais en mésocosmes seront mis en place en fonction de la diversité, de la capacité […]

The main objective is to advance the knowledge of porcupine crab for the purpose of developing a commercial fishery in Canada, Nunavut, Newfoundland and Labrador and to develop a suite a value added crab products. The aim of the current study is to extract, quantify and characterize chitin and astaxanthin from porcupine crab shells as […]

The human intestinal tract contains trillions of bacteria that greatly influence the way we absorb and use the nutrients in our food. In the context of obesity, the balance of this environment is impaired which could lead to the worsening of diseases related to obesity, such as type 2 diabetes. This highlights the need for […]

L’objectif du projet est de tester l’adaptation de la forme des fleurs de l’Impatiente du cap aux milieux urbains à l’aide d’une expérience de type jardin commun. Des plants de l’Impatiente du cap provenant de 16 populations de 4 villes canadiennes différentes seront étudiées: Toronto, Ottawa, Montréal et Québec. Dans chaque ville, les graines de […]

Overexpression of the calcium channel – Transient receptor potential vanilloid type (TRPV6) occurs in many epithelial type cancers [4] and hematological malignancy such as leukemia [7]. However, no correlation of TRPV6 to the deadly bone marrow cancer, multiple myeloma, has been made so far. Recently, we have detected the strong expression of TRPV6 protein in […]

The current innovative research project has three objectives to address current deficiencies in contaminated sites assessment and remediation: (1) To develop a rating system that defines the stages of recovery/impact at marine sites based on intertidal community structure and pollution tolerance/sensitivity/intolerance of resident species. (2) To develop methodology for the assessment of environmental stress levels […]