Syntheses of novel 3,5-bis(benzylidene)-4-piperidone derivatives as potential anticancer agents

The principal objective of this proposal is to discover novel drugs to treat colon cancers. Currently colon cancer is a huge medical problem and there are many disadvantages to current drug therapies. These disadvantages include their ineffectiveness to completely eradicate cancers, causing toxic side effects and the development of multidrug resistance. A group of compounds […]

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Accelerate Getting Research into Practice (A-GRIP)

There is a growing disconnect between the areas of focus in innovation research occurring at universities and the practical concerns, needs and direction of the animal production industry. Research has shown that ongoing communication and interaction between researchers and end-users is necessary, both before and during research, in order to ensure that research conducted is […]

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Next-generation pulmonary 3D models and to unravel the role of complex immune-structural cell interactions in chronic obstructive pulmonary disease (COPD)

No cure currently exists for COPD, which affects 2.6million Canadians and include airway-scarring and destruction of the airspaces due to chronic cigarette smoking. In the lungs, the airways are lined with a structural-cell layer, called an epithelium, which much like our skin, protects the lung from inhaled particles including cigarette smoke. The epithelium communicates with […]

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Fabrication of a cost-effective microfluidic eye model for high throughput screening and testing of ophthalmic materials and drugs

Toxicity testing of ophthalmic products is an important step in developing new eye products. Microfluidic devices, such as lab-on-a-chip, are an effective way to evaluate the toxicity of new products prior to animal testing. However, the current methods to create these microfluidic chips are too time-consuming and expensive for high-throughput screening. The objective of this […]

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Dietary counselling plus fish oil supplementation in the treatment of generalized anxiety disorder: A randomized wait-list controlled pilot trial

Generalized anxiety disorder (GAD) has a large impact on the wellbeing of Canadians. Some people find the available treatments helpful, but some do not. There is a need for new treatment approaches. This project will provide 6 nutritional counselling sessions along with fish oil supplementation to 40 adult women with moderate to severe GAD. The […]

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Multi-sensor technology to safely navigate exercise in extreme temperatures

Extreme temperatures increase the risk when exercising. The early recognition of symptoms and physiological changes (i.e. heart rate alterations) can help to prevent temperature-related illnesses. Wearable devices available in the market are key to monitor health parameters but not to indicate risk exposure. Thus, we aim to identify the best combination of health parameters to […]

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Investigating the effect of REAP, a rare earth element and micronutrient fertilizer, on cannabis physiological growth variables, yield and product quality.

The research proposed will produce critical knowledge relevant to the cannabis industry, allowing for the production of high-quality plant material with optimum cannabinoid concentrations. The project will investigate a rare earth element supplemental fertilizer (REAP) effects on cannabis growth, flower yield and cannabinoid concentrations. We will evaluate application of REAP at three rates and hypothesize […]

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Impact of the COVID-19 pandemic on drug safety surveillance: An analysis of spontaneous reporting databases in Canada and the United States

The COVID-19 pandemic had an impact on everyone and was heavily covered by the media. Studies have shown that the pandemic itself and the media coverage might have influenced the number of adverse drug reactions that were reported to regulatory agencies. This project aims at determining how it affected the reporting of all adverse drug […]

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Updating the 2008 Prairie North Health Region Health Status Report

The purpose of the Health Status report is to provide a snapshot of the health of the population served by the Prairie North Regional Health Authority (PNRHA). Its vision of “healthy people in healthy communities” serves as the driving force of the report in hopes to better understand the social, economic, physical, political and cultural […]

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Une nouvelle plateforme de nanothérapie contre le cancer de la prostate basée sur la photo-ablation, à l’aide d’imagerie et de surveillance

Prostate Cancer has become the most diagnosed cancer in men in Canada. Nanoparticles have a myriad of unique properties, the most striking is their incredible ability to absorb light and convert this energy into intense heat. Therefore, the placement of particles to a tumor, dissipating extreme near-field energy, would cause complete ablation. In realizing this […]

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Évaluation des initiatives favorisant l’utilisation optimale des médicaments biosimilaires dans le secteur des payeurs privés

iA Groupe financier est un groupement de sociétés d’assurance et de gestion de patrimoine des plus importants au Canada. Plus de la moitié des personnes couvertes par iA viennent du Québec. Le 6 juillet 2021, Régie d’assurance maladie du Québec (RAMQ) a annoncé une transition des patients utilisant des médicaments biologiques de référence, c’est-à-dire des […]

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