Assessments of cortical responses to non-invasive brain stimulation

The proposed research project will aim to measure the reliability of changes in brain activity induced by repetitive transcranial magnetic stimulation (rTMS). rTMS is a non-invasive therapy that has been used to evoke changes in local and network-level brain activity in various clinical populations, including stroke and depression. The proposed project will test rTMS effectiveness […]

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Preclinical optimization of safety and duration of cold plasma against cancer

The goal of this research is to reduce the risks of recurrence and the treatment side effects for breast cancer patients by combining a new cold plasma technology to the standard of care (surgery and radiotherapy). Cold plasma generates locally specific reactive oxygen species that can kill cancer cells. It could be delivered directly in […]

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Development of selective cannabinoid treatments for neuroinflammation

Inflammation of the brain is a symptom of many different types of brain diseases such as Alzheimer’s disease, multiple sclerosis, depression, stroke, and traumatic brain injury. If left untreated, the inflammation can become a chronic problem that causes further damage to the brain. Different types of cannabinoids are a promising source of potential treatments to […]

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Assessing the mental health impact of COVID-19 on Canadians: Phase 2

MHRC is conducting ongoing polling of Canadians to assess the effect of COVID-19 on mental health. We require additional support to expand our capacity to analyze the datasets we are creating. Our poll is extensive including a number of markers of mental health along with an array of demographic controls and is rolled out every […]

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The Relationship between Psychophysiological Measures of Emotion and Applied Effort

Physical inactivity is a major public health concern. While this is a multifaceted issue, one approach to increase interest and engagement in exercise is to make it more immersive. Previous research has shown that emotionally driven content can increase the overall experience as well as an individual’s performance during exercise. However, the relationship between emotionally […]

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Assessment of a novel chemical entity (TRV 1387) in the treatment of tau-related neuropathology and behavioral impairment in a transgenic mouse model of Alzheimer’s disease.

The onset of symptoms in Alzheimer’s Disease, Picks disease, progressive supranuclear palsy and cortical basal degeneration are connected to the formation of insoluble deposits of the tau protein in the brain, also known as neurofibrillary tangles (NFT). The Treventis Corporation has developed new chemicals that are designed to prevent the formation of NFT, which may […]

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Exploring the antidepressant response to 2-Bromo-LSD in female mice

Lysergic acid diethylamide (LSD) and other psychedelic drugs have been shown to have therapeutic effects, including for the treatment of depression. However, their hallucinogenic effects may represent an undesirable side effect. Non-hallucinogenic derivatives of these drugs represent a promising alternative; one such alternative is 2-bromo-LSD (BetterLife drug TD-0148A), but data on its effectiveness as an […]

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Controlling inhaled gasses for novel clinicalapplications

The general objective of this MITACS project is to introduce RespirAct (TM) as a unique device that provides a precise, repeatable vasoactive stimulus to extend the capabilities of imaging modalitites such as PET, CT, MRI and ultrasound. In the first project, the development and standardization of the cerebrovascular stress test will provde a means to […]

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Genome-scale metabolic models for the characterization of genetically modified microalgae for cannabinoid production

Algae-C is a company specialized in algal biomass production. It enables on-site production of algae for a wide variety of sectors (aquaculture, nutraceutical, cosmetic and biofuel). To date, many fuels, pharmaceuticals and cosmetic products are extracted from plants. These valuable plant natural products (PNPs) are often produced in low quantities in plants and extraction methods […]

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Characterization of Simple In Vivo Models of Charcot Marie Tooth (CMT) Disease

Modelis is a drug discovery platform company focused solely on rare, genetic diseases. Our unique approach combines genetically-engineered worms which are ‘avatars’ of human patients, with high-throughput drug screening. This results in a dramatically accelerated drug discovery process. Our platform is perfectly suited for genes that are evolutionarily and functionally conserved such as FIG4, and […]

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