PARP inhibitors are an FDA-approved treatment for breast, ovarian and prostate cancers. This project aims to develop 3 new classes of PARP inhibitors, 2 of which can target multiple pathways with a single drug, helping to prevent resistance to the PARP inhibitors and enabling the combination of 2 drug treatments without the added side effects […]

Le cancer professionnel, une cause de mortalité fréquente en France et au Canada, atteint de façon préférentielle certaines catégories d’emploi, pour lesquelles ce sujet doit être abordé dès la formation. Les apprentis sont particulièrement exposés aux agents cancérogènes et leur âge implique une exposition prolongée: 25% d’entre eux sont en contact régulier avec au moins […]

Marine biofouling, which is the growth of organisms on ocean infrastructure, is a widespread problem with substantial economic and environmental costs. This project undertaken by the intern will develop dynamic tests of a novel graphene-based antifouling coating designed by Graphite Innovation & Technologies (GIT). The dynamic tests involve generating water flow over the coating surface, […]

This project is a collaboration between the Emily Carr Institute of Art and Design and Molecular You. Molecular You are a health-tech start-up on a mission to help everyone live longer healthier lives using a new type of digital health experience that can spot early warning signs of chronic disease and tell you exactly what […]

UV light is known for its antimicrobial properties. In this project, we expect to use a proprietary lamp which will provide a specific light that will target bacterial, fungal and viral strains commonly found in health care facilities. Results of the project will have a direct impact in the sterilization of areas with a high […]

Our immune system Is designed to protect us from harmful agents. It must initiate a rapid potent inflammatory response to eliminate invading pathogens. Although similar to the eradication of pathogens, the inflammatory response can also occur following a sterile injury and is required for tissue repair and wound healing. This includes trauma, ischaemia-reperfusion injury, autoimmunity […]

In Sub-Saharan Africa, bovine Tuberculosis (bTB) is known to infect nearly all mammals, and is a threat to wildlife and livestock. However, the roles of biodiversity and host community composition on outbreak dynamics are still not clearly understood. Close contacts and the sharing of resources, such as food and water, are thought to be drivers […]

Challenge: The most critical step in discovering future medications is the identification of the initial hit compounds (“leads”) that interact with target proteins and which have the desired properties. The search for and validation of potential lead compounds is a major challenge for launching drug discovery programs as this process requires highly specialized expertise, expensive […]

The proposed study has three objectives: Objective 1. Develop KOA microsimulation model: To develop and validate a Knee-OA population-based microsimulation model (POHEM-KOA) using the previously developed POHEM-OA model. Objective 2. Perform cost-effectiveness analysis of non-pharmacological therapies for KOA: To use POHEM-KOA in conducting a cost-effectiveness analysis of treatment strategies, including exercise therapy and weight reduction, […]

Prolonged morphine treatment is known to cause an up-regulation of ORL1 receptors in the spinal cord (12, 13), which in turn is believed to contribute to the development of morphine tolerance by altering ?-opioid receptor mediate modulation of N-type calcium channels. Indeed, ORL1 antagonists can reverse the development of tolerance, and ORL1 knockout can mediate […]

The Health in HIPPY Homes project seeks to explore refugee mothers’ and families’ health during resettlement in Calgary, Alberta, Canada, and the various factors that affect their wellbeing during this period. Additionally, we are interested in better understanding the potential impacts that participating in the Home Instruction for Parents of Preschool Youngsters (HIPPY) program has […]

Late-stage lung cancer patients with non-small cell lung cancers who demonstrate high levels of PDL1 expression have better outcomes when placed on a combined treatment program of both immunotherapy and chemotherapy. There is a subset of patients that respond well to pembrolizumab, an immunotherapy drug, alone as an initial treatment path, but there are no […]