Modelis is a drug discovery platform company focused solely on rare, genetic diseases. Our unique approach combines genetically-engineered worms which are ‘avatars’ of human patients, with high-throughput drug screening. This results in a dramatically accelerated drug discovery process. Our platform is perfectly suited for genes that are evolutionarily and functionally conserved such as FIG4, and […]

Designing new anticancer agents using structure based drug design and the 3D structure of the biological target is becoming an increasingly important field of study. The main objective of this project is to develop and identify anticancer drug candidate(s) for advanced preclinical testing, with the end goal of identifying drug candidates suitable for clinical trials […]

Primary biliary cholangitis (PBC) is an autoimmune liver disease that is associated with multiple symptoms, including fatigue, pruritus, bone disease, emotional distress and impaired health related quality of life. There is evidence to support the important role of exercise and nutrition in improving symptoms and reducing disease-related complications in people with PBC. Working together with […]

Nous étudierons les mécanismes moléculaires des interactions virus-hôte du virus de la diarrhée épidémique porcine (PEDV), un important coronavirus porcin à ARN enveloppé. Ce virus est responsable de graves pertes économiques et constitue le principal agent pathogène émergent du porc au Canada et dans le monde. Nous proposons d’étudier les mécanismes moléculaires des interactions hôte-PEDV, […]

Fish and fish habitat are shared resources that provide social, cultural, economic, ecological, and spiritual benefits to Canadians, particularly for Indigenous Peoples. In Eeyou Istchee (Cree territory), healthy aquatic ecosystems are integral parts of Cree cultural wellbeing. Several fish and fish habitat compensation projects have occurred in this region to compensate development. However, there has […]

The COVID-19 pandemic affected every aspect of our lives, and recreational water facilities were not immune to this with several questions and concerns about potential exposure to the virus at these facilities. This research project aims to understand experiences, needs, and opportunities towards the use of pools in residential buildings and hotels. Two groups of […]

Common bean is a promising commodity to ensure food security and increase diet quality due to its high content of protein, minerals, and vitamins. To contribute to the increase of the genetic gain in breeding programs for agronomic and quality traits, the project aims to study the genetic architecture of agronomic and quality traits, and […]

With chronic inflammatory diseases such as arthritis affecting the spine, a major clinical problem is that disease can advance over years with unrecognized persisting inflammation. Recently, we discovered that elevated concentration of certain substances in blood considered together, are highly associated with persisting local inflammation. This study will use data gathered from the blood chemistry […]

Prescribed fire is an important tool to maintain the productivity and diversity of grasslands. Remnant grasslands within the jurisdiction of the Meewasin Valley Authority are thought to require fire to both maintain ecosystem integrity and to reduce the danger of wildfire. While there are many individual studies demonstrating the value of prescribed fire in Western […]

This project will provide essential technical support and experimental plant materials for my Ph.D. project studying the leaf development of a non-vascular plant, the Physcomitrium patens. The mutant lines I will obtain from this project will be used to study the whole developmental process of the moss leaf. The mutant line with a plasma membrane […]

McMaster’s Health Information Research Unit has a long-established track record of identifying and sharing the highest quality, clinically relevant medical research to support healthcare professionals in staying up to date with the latest evidence so they can provide the best care to their patients. We have developed and used traditional search filters to help in […]

Positional plagiocephaly is an increasingly common form of cranial deformity in infants, affecting approximately 40% of infants under the age of 1. While it is not associated with developmental defects or learning impairments, there can be long term aesthetic implications for deformity that is not appropriately addressed early in life. Early identification of plagiocephaly and […]