Previous research has shown that most of the mammalian genome is transcribed, while most mammalian transcripts do not code for proteins and may instead be functional themselves. Non-coding RNAs play critical roles in some of the most fundamental processes in molecular biology. The vast majority of mammalian non-coding transcripts are constituted by long non-coding RNAs […]

Whether or not to undergo prenatal screening to assess the risk of certain genetic conditions in the fetus, and if so deciding among available prenatal screening tests, is a difficult decision faced by all pregnant women and their partners. However, few are aware of the implications of the various options. With shared decision making (SDM), […]

Forests of BC are under stress due to changing climates. This introduces uncertainty in the wood properties and resulting wood products that will be derived from these forests. Subalpine fir trees contribute to a significant portion of wood that is manufactured into pulp in Canada, and little is known about how these trees respond to […]

A class of compounds the work will be done are tetrahydrofuran-incorporating polyketide macrolides. This class of compounds are natural products found in diverse marine and terrestrial environments, and it has been found to show potentially useful activity in a variety of biological assays. In order to explore and expand this family of macrolides, it is […]

Acute respiratory distress syndrome (ARDS) is a life-threatening condition with a high mortality. Currently, there are no proven pharmacological therapies available for the management of ARDS patients. Mesenchymal Stem Cells (MSCs) have been shown to be interesting candidates for treating ARDS. But their therapeutic effects as demonstrated in animal models and clinical trials have been […]

As diabetes continues to rise globally, the risk of developing chronic diabetic complications greatly increases. Among these complications, non-alcoholic fatty liver disease (NAFLD) is a serious liver disease that can contribute to major scarring of the liver and this may ultimately lead to liver failure. To develop a better understanding of the processes involved in […]

During this internship, my goal is to create a dinitrogen molecule that fits into the frustrated Lewis pair model. This molecule will be used to replace currently existing polluting fertilizers. To achieve this goal, the internship is divided into three steps: -The first consists of synthesizing a molecule containing N2. -Next, we will try to […]

Dans ce projet de recherche, l’objectif est d’étudier et d’analyser différentes molécules synthétisées afin de découvrir leur réactivité avec le CO2. Le projet se concentrera donc sur la mise en place et la production de ces différentes molécules, dans un premier temps. Par la suite, l’application de ces molécules avec du dioxyde de carbone (CO2) […]

La fatigue représente le symptôme le plus fréquemment rapporté par les patients atteints de la sclérose en plaques (SP). Cette fatigue liée à la SP s’avère limitante pour les tâches du quotidien. Jusqu’à maintenant, peu d’études ont mesuré la fatigue neuromusculaire à la suite d’un exercice fatigant exigeant de larges masses musculaires comme celles exigées […]

The metabolic theory of ecology states that the rate at which an organism uses energy is a key driver of its ecology and can provide a framework for the study of its behaviour, life history, population dynamics, and impact on the ecosystem. Despite being an important aspect of a species’ biology, metabolic rate has not […]

Free ranging and wild animals sometimes experience challenges of physical wellbeing and optimal movement ability, but assessing if they are stressed in these situations can prove difficult. My research will be focusing on a population of Japanese macaques on Awaji Island, Japan that are born with very high incidences of limb malformations that cause physical […]

Preliminary data suggest a possible involvement of the melatonin MT1 but not MT2 receptor in the pathophysiology of bipolar disorder. The main objective of this short project is therefore to investigate at preclinical level whether the first selective MT1 receptor partial agonist to be synthesized (UCM871) can improve the bipolar symptomatology of the mice genetically […]